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Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma

Sonic Hedgehog (Shh) is abnormally expressed in pancreatic cancer and is associated with disease onset and progression. Inhibition of Shh signaling is thus an attractive clinical target for therapeutic intervention. Most efforts to block Shh signaling have focused on inhibitors of Smoothened, which...

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Detalles Bibliográficos
Publicado en:Oncogene
Autores principales: Petrova, E, Matevossian, A, Resh, MD
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513646/
https://ncbi.nlm.nih.gov/pubmed/24469057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.575
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