Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis

The orphan nuclear receptor Nr4a2 is known to modulate both inflammatory and metabolic processes, but the mechanism by which it regulates innate inflammatory homeostasis has not been adequately addressed. This study shows that exposure to ligands for Toll-like receptors (TLRs) robustly induces Nr4a2...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mahajan, Sahil, Saini, Ankita, Chandra, Vemika, Nanduri, Ravikanth, Kalra, Rashi, Bhagyaraj, Ella, Khatri, Neeraj, Gupta, Pawan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513091/
https://ncbi.nlm.nih.gov/pubmed/25953901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638064
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