Human IL10 Gene Repression by Rev-erbα Ameliorates Mycobacterium tuberculosis Clearance

Nuclear receptors modulate macrophage effector functions, which are imperative for clearance or survival of mycobacterial infection. The adopted orphan nuclear receptor Rev-erbα is a constitutive transcriptional repressor as it lacks AF2 domain and was earlier shown to be present in macrophages. In...

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Detalhes bibliográficos
Main Authors: Chandra, Vemika, Mahajan, Sahil, Saini, Ankita, Dkhar, Hedwin K., Nanduri, Ravikanth, Raj, Ella B., Kumar, Ashwani, Gupta, Pawan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624449/
https://ncbi.nlm.nih.gov/pubmed/23449984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455915
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