The Active Form of Vitamin D Transcriptionally Represses Smad7 Signaling and Activates Extracellular Signal-regulated Kinase (ERK) to Inhibit the Differentiation of a Inflammatory T Helper Cell Subset and Suppress Experimental Autoimmune Encephalomyelitis

The ability of the active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), to transcriptionally modulate Smads to inhibit Th17 differentiation and experimental autoimmune encephalomyelitis (EAE) has not been adequately studied. This study reports modulation of Smad signaling by the s...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Nanduri, Ravikanth, Mahajan, Sahil, Bhagyaraj, Ella, Sethi, Kanupriya, Kalra, Rashi, Chandra, Vemika, Gupta, Pawan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2015
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424354/
https://ncbi.nlm.nih.gov/pubmed/25809484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621839
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