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Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan
Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...
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| Publicat a: | Front Pharmacol |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4510998/ https://ncbi.nlm.nih.gov/pubmed/26257651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00147 |
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