Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

Enhanced DNA damage repair is one mechanism involved in colon cancer drug resistance. Thus, targeting molecular components of repair pathways with specific small molecule inhibitors may improve the efficacy of chemotherapy. ABT-888 and VE-821, inhibitors of poly-ADP-ribose-polymerase (PARP) and the...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Abu-Sanad, Atlal, Wang, Yunzhe, Hasheminasab, Fatemeh, Panasci, Justin, Noë, Alycia, Rosca, Lorena, Davidson, David, Amrein, Lilian, Sharif-Askari, Bahram, Aloyz, Raquel, Panasci, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510998/
https://ncbi.nlm.nih.gov/pubmed/26257651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00147
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