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The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines
Poly [ADP-ribose] polymerase-1 (PARP-1) localizes rapidly to sites of DNA damage and has been associated with various repair mechanisms including base excision repair (BER) and homologous recombination/non-homologous end joining (HRR/NHEJ). PARP-1 acts by adding poly-ADP ribose side chains to target...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857790/ https://ncbi.nlm.nih.gov/pubmed/23054213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9886-7 |
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