A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid For Patients With Glioblastoma

PURPOSE: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in pre-clinical models. We evaluated the addition of VPA to standard radiation therapy (RT) and temozolomide (TMZ) in patients with newl...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Krauze, Andra V., Myrehaug, Sten D., Chang, Michael G., Holdford, Diane J., Smith, Sharon, Shih, Joanna, Tofilon, Philip J., Fine, Howard A., Camphausen, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510472/
https://ncbi.nlm.nih.gov/pubmed/26194676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2015.04.038
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