AT-33 A PHASE II STUDY OF CONCURRENT RADIATION THERAPY, TEMOZOLOMIDE AND THE HISTONE DEACETYLASE INHIBITOR VALPROIC ACID FOR PATIENTS WITH GLIOBLASTOMA MULTIFORME

BACKGROUND: Glioblastoma (GBM) remains an aggressive brain tumor with poor prognosis. Valproic acid (VPA) is an antiepileptic agent that has been shown to have HDACi activity and to radiosensitize GBM cells in preclinical models. This phase II study aimed to determine if the addition of VPA to stand...

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Main Authors: Krauze, Andra V., Myrehaug, Sten D., Chang, Michael G., Holdford, Diane J., Smith, Sharon, Shih, Joanna, Tofilon, Peter, Fine, Howard, Camphausen, Kevin A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217812/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou237.33
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