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Late toxicity in long-term survivors from a phase 2 study of concurrent radiation therapy, temozolomide and valproic acid for newly diagnosed glioblastoma

BACKGROUND: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor activity shown to enhance overall survival and progression free survival in patients with newly diagnosed glioblastoma (GBM). This reports on the late toxicity of the VPA/radiotherapy (RT)/temozolomide (TMZ)...

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Dettagli Bibliografici
Pubblicato in:Neurooncol Pract
Autori principali: Krauze, Andra V, Mackey, Megan, Rowe, Lindsay, Chang, Michal G, Holdford, Diane J, Cooley, Theresa, Shih, Joanna, Tofilon, Philip J, Camphausen, Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213944/
https://ncbi.nlm.nih.gov/pubmed/30402263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nop/npy009
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