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Late toxicity in long-term survivors from a phase 2 study of concurrent radiation therapy, temozolomide and valproic acid for newly diagnosed glioblastoma

BACKGROUND: Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor activity shown to enhance overall survival and progression free survival in patients with newly diagnosed glioblastoma (GBM). This reports on the late toxicity of the VPA/radiotherapy (RT)/temozolomide (TMZ)...

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Detalhes bibliográficos
Publicado no:Neurooncol Pract
Main Authors: Krauze, Andra V, Mackey, Megan, Rowe, Lindsay, Chang, Michal G, Holdford, Diane J, Cooley, Theresa, Shih, Joanna, Tofilon, Philip J, Camphausen, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213944/
https://ncbi.nlm.nih.gov/pubmed/30402263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nop/npy009
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