Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

Rapamycin extends lifespan and attenuates age-related pathologies in mice when administered through diet at 14 parts per million (PPM). Recently, we reported that daily intraperitoneal injection of rapamycin at 8 mg/kg attenuates mitochondrial disease symptoms and progression in the Ndufs4 knockout...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Johnson, Simon C., Yanos, Melana E., Bitto, Alessandro, Castanza, Anthony, Gagnidze, Arni, Gonzalez, Brenda, Gupta, Kanav, Hui, Jessica, Jarvie, Conner, Johnson, Brittany M., Letexier, Nicolas, McCanta, Lanny, Sangesland, Maya, Tamis, Oliver, Uhde, Lauren, Van Den Ende, Alex, Rabinovitch, Peter S., Suh, Yousin, Kaeberlein, Matt
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510413/
https://ncbi.nlm.nih.gov/pubmed/26257774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00247
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