mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration, cardiomyopathies, cancer, diabetes, and pathologies of aging. Severe mitochondrial defects can result in childhood disorders such as Leigh syndrome, for which there are no effective t...

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Autors principals: Johnson, Simon C., Yanos, Melana E., Kayser, Ernst-Bernhard, Quintana, Albert, Sangesland, Maya, Castanza, Anthony, Uhde, Lauren, Hui, Jessica, Wall, Valerie Z., Gagnidze, Arni, Oh, Kelly, Wasko, Brian M., Ramos, Fresnida J., Palmiter, Richard D., Rabinovitch, Peter S., Morgan, Philip G., Sedensky, Margaret M., Kaeberlein, Matt
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055856/
https://ncbi.nlm.nih.gov/pubmed/24231806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1244360
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