mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration, cardiomyopathies, cancer, diabetes, and pathologies of aging. Severe mitochondrial defects can result in childhood disorders such as Leigh syndrome, for which there are no effective t...

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Главные авторы: Johnson, Simon C., Yanos, Melana E., Kayser, Ernst-Bernhard, Quintana, Albert, Sangesland, Maya, Castanza, Anthony, Uhde, Lauren, Hui, Jessica, Wall, Valerie Z., Gagnidze, Arni, Oh, Kelly, Wasko, Brian M., Ramos, Fresnida J., Palmiter, Richard D., Rabinovitch, Peter S., Morgan, Philip G., Sedensky, Margaret M., Kaeberlein, Matt
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055856/
https://ncbi.nlm.nih.gov/pubmed/24231806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1244360
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