Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

Rapamycin extends lifespan and attenuates age-related pathologies in mice when administered through diet at 14 parts per million (PPM). Recently, we reported that daily intraperitoneal injection of rapamycin at 8 mg/kg attenuates mitochondrial disease symptoms and progression in the Ndufs4 knockout...

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Podrobná bibliografie
Vydáno v:Front Genet
Hlavní autoři: Johnson, Simon C., Yanos, Melana E., Bitto, Alessandro, Castanza, Anthony, Gagnidze, Arni, Gonzalez, Brenda, Gupta, Kanav, Hui, Jessica, Jarvie, Conner, Johnson, Brittany M., Letexier, Nicolas, McCanta, Lanny, Sangesland, Maya, Tamis, Oliver, Uhde, Lauren, Van Den Ende, Alex, Rabinovitch, Peter S., Suh, Yousin, Kaeberlein, Matt
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510413/
https://ncbi.nlm.nih.gov/pubmed/26257774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00247
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