Structural Integrity of the Ribonuclease H domain in HIV-1 Reverse Transcriptase

The mature form of reverse transcriptase (RT) is a heterodimer comprising the intact 66-kDa subunit (p66) and a smaller 51-kDa subunit (p51) that is generated by removal of most of the RNase H (RNH) domain from a p66 subunit by proteolytic cleavage between residues 440/441. Viral infectivity is elim...

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Bibliografiska uppgifter
I publikationen:Proteins
Huvudupphovsmän: Slack, Ryan L., Spiriti, Justin, Ahn, Jinwoo, Parniak, Michael A., Zuckerman, Daniel M., Ishima, Rieko
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509971/
https://ncbi.nlm.nih.gov/pubmed/26061827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24843
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