Entire-Dataset Analysis of NMR Fast-Exchange Titration Spectra: a Mg(2+) Titration Analysis for HIV-1 Ribonuclease H Domain

This article communicates our study to elucidate the molecular determinants of weak Mg(2+) interaction with the ribonuclease H (RNH) domain of HIV-1 reverse transcriptase in solution. Since the interaction is weak (a ligand-dissociation constant > 1 mM), non-specific Mg(2+) interaction with the p...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Karki, Ichhuk, Christen, Martin T., Spiriti, Justin, Slack, Ryan L., Oda, Masayuki, Kanaori, Kenji, Zuckerman, Daniel M., Ishima, Rieko
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850897/
https://ncbi.nlm.nih.gov/pubmed/27973819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b08323
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