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New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans
Streptococcus mutans is a major aetiological agent of dental caries. Formation of biofilms is a key virulence factor of S. mutans. Drugs that inhibit S. mutans biofilms may have therapeutic potential. Dihydrofolate reductase (DHFR) plays a critical role in regulating the metabolism of folate. DHFR i...
Gorde:
| Argitaratua izan da: | Int J Antimicrob Agents |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4509821/ https://ncbi.nlm.nih.gov/pubmed/26022931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2015.03.015 |
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