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New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans

Streptococcus mutans is a major aetiological agent of dental caries. Formation of biofilms is a key virulence factor of S. mutans. Drugs that inhibit S. mutans biofilms may have therapeutic potential. Dihydrofolate reductase (DHFR) plays a critical role in regulating the metabolism of folate. DHFR i...

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Bibliografiske detaljer
Udgivet i:Int J Antimicrob Agents
Main Authors: Zhang, Qiong, Nguyen, Thao, McMichael, Megan, Velu, Sandanandan, Zou, Jing, Zhou, Xuedong, Wu, Hui
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509821/
https://ncbi.nlm.nih.gov/pubmed/26022931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2015.03.015
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