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Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence
Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms. Therefore, the inhibition of GtfBCD would provide anti-virulence therapeutics. Here a small molecule library of 500,000 small molecule compounds was screened in silico ag...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5519559/ https://ncbi.nlm.nih.gov/pubmed/28729722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06168-1 |
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