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Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes
INTRODUCTION: During aging, advanced glycation end products (AGEs) accumulate in articular cartilage. In this study we determined whether AGEs induce endoplasmic reticulum (ER) stress and studied the ER stress-activated pathways that stimulate cyclooxygenase-2 (COX-2) expression in human chondrocyte...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4509732/ https://ncbi.nlm.nih.gov/pubmed/22982228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2012.08.021 |
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