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Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

INTRODUCTION: During aging, advanced glycation end products (AGEs) accumulate in articular cartilage. In this study we determined whether AGEs induce endoplasmic reticulum (ER) stress and studied the ER stress-activated pathways that stimulate cyclooxygenase-2 (COX-2) expression in human chondrocyte...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Rasheed, Zafar, Haqqi, Tariq M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509732/
https://ncbi.nlm.nih.gov/pubmed/22982228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2012.08.021
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