Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

BACKGROUND: Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes to the development of DCM. ROCK targets several sarcomeric proteins including...

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Bibliografische gegevens
Gepubliceerd in:Cardiovasc Diabetol
Hoofdauteurs: Waddingham, Mark T, Edgley, Amanda J, Astolfo, Alberto, Inagaki, Tadakatsu, Fujii, Yutaka, Du, Cheng-Kun, Zhan, Dong-Yun, Tsuchimochi, Hirotsugu, Yagi, Naoto, Kelly, Darren J, Shirai, Mikiyasu, Pearson, James T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
Onderwerpen:
Original Investigation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509700/
https://ncbi.nlm.nih.gov/pubmed/26194354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0256-6
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