Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

BACKGROUND: Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes to the development of DCM. ROCK targets several sarcomeric proteins including...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Waddingham, Mark T, Edgley, Amanda J, Astolfo, Alberto, Inagaki, Tadakatsu, Fujii, Yutaka, Du, Cheng-Kun, Zhan, Dong-Yun, Tsuchimochi, Hirotsugu, Yagi, Naoto, Kelly, Darren J, Shirai, Mikiyasu, Pearson, James T
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509700/
https://ncbi.nlm.nih.gov/pubmed/26194354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0256-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados