Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

BACKGROUND: Impaired actin–myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes to the development of DCM. ROCK targets several sarcomeric proteins including...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovasc Diabetol
Main Authors: Waddingham, Mark T, Edgley, Amanda J, Astolfo, Alberto, Inagaki, Tadakatsu, Fujii, Yutaka, Du, Cheng-Kun, Zhan, Dong-Yun, Tsuchimochi, Hirotsugu, Yagi, Naoto, Kelly, Darren J, Shirai, Mikiyasu, Pearson, James T
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509700/
https://ncbi.nlm.nih.gov/pubmed/26194354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0256-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items