Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation

OBJECTIVES: Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diab...

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Détails bibliographiques
Auteurs principaux: Pearson, James T, Jenkins, Mathew J, Edgley, Amanda J, Sonobe, Takashi, Joshi, Mandar, Waddingham, Mark T, Fujii, Yutaka, Schwenke, Daryl O, Tsuchimochi, Hirotsugu, Yoshimoto, Misa, Umetani, Keiji, Kelly, Darren J, Shirai, Mikiyasu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734116/
https://ncbi.nlm.nih.gov/pubmed/24059472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-111
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