Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation

OBJECTIVES: Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diab...

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Dettagli Bibliografici
Autori principali: Pearson, James T, Jenkins, Mathew J, Edgley, Amanda J, Sonobe, Takashi, Joshi, Mandar, Waddingham, Mark T, Fujii, Yutaka, Schwenke, Daryl O, Tsuchimochi, Hirotsugu, Yoshimoto, Misa, Umetani, Keiji, Kelly, Darren J, Shirai, Mikiyasu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734116/
https://ncbi.nlm.nih.gov/pubmed/24059472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-111
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