IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1(+) endosomes

IQ motif–containing GTPase-activating protein 1 (IQGAP1) is a cytoskeleton-interacting scaffold protein. CXCR4 is a chemokine receptor that binds stromal cell–derived factor-1 (SDF-1; also known as CXCL12). Both IQGAP1 and CXCR4 are overexpressed in cancer cell types, yet it was unclear whether thes...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Bamidele, Adebowale O., Kremer, Kimberly N., Hirsova, Petra, Clift, Ian C., Gores, Gregory J., Billadeau, Daniel D., Hedin, Karen E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508899/
https://ncbi.nlm.nih.gov/pubmed/26195666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411045
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