SDF-1 signaling via the CXCR4-TCR heterodimer requires PLC-β3 and PLC-γ1 for distinct cellular responses

The CXCR4 chemokine receptor is a G protein-coupled receptor (GPCR) that signals in T lymphocytes by forming a heterodimer with the T cell antigen receptor (TCR). CXCR4 and TCR functions are consequently highly cross-regulated, affecting T cell immune activation, cytokine secretion, and T cell migra...

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Detalhes bibliográficos
Main Authors: Kremer, Kimberly N., Clift, Ian C., Miamen, Alexander G., Bamidele, Adebowale O., Qian, Nan-Xin, Humphreys, Troy D., Hedin, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140596/
https://ncbi.nlm.nih.gov/pubmed/21705626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100820
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