Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented Aβ oligomers-induced inhibition of long-term potentiat...

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Udgivet i:Sci Rep
Main Authors: Chang, Lan, Cui, Wei, Yang, Yong, Xu, Shujun, Zhou, Wenhua, Fu, Hongjun, Hu, Shengquan, Mak, Shinghung, Hu, Juwei, Wang, Qin, Pui-Yan Ma, Victor, Chung-lit Choi, Tony, Dik-lung Ma, Edmond, Tao, Liang, Pang, Yuanping, Rowan, Michael J., Anwyl, Roger, Han, Yifan, Wang, Qinwen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508546/
https://ncbi.nlm.nih.gov/pubmed/26194093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10256
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