Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin

Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and γ-aminobutyric acid subtype...

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Detalhes bibliográficos
Main Authors: Luo, Jialie, Li, Wenming, Zhao, Yuming, Fu, Hongjun, Ma, Dik-Lung, Tang, Jing, Li, Chaoying, Peoples, Robert W., Li, Fushun, Wang, Qinwen, Huang, Pingbo, Xia, Jun, Pang, Yuanping, Han, Yifan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888406/
https://ncbi.nlm.nih.gov/pubmed/20404346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111286
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