Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin

Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and γ-aminobutyric acid subtype...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Luo, Jialie, Li, Wenming, Zhao, Yuming, Fu, Hongjun, Ma, Dik-Lung, Tang, Jing, Li, Chaoying, Peoples, Robert W., Li, Fushun, Wang, Qinwen, Huang, Pingbo, Xia, Jun, Pang, Yuanping, Han, Yifan
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Neurobiology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888406/
https://ncbi.nlm.nih.gov/pubmed/20404346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111286
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