Batf3 maintains Irf8 autoactivation for commitment of a CD8α(+) cDC clonogenic progenitor

The transcription factors Batf3 and IRF8 are required for development of CD8α(+) conventional dendritic cells (cDCs), but the basis for their actions was unclear. Here, we identify two novel Zbtb46(+) progenitors that separately generate CD8α(+) and CD4(+) cDCs and arise directly from the common DC...

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Publicado no:Nat Immunol
Main Authors: Grajales-Reyes, Gary E., Iwata, Arifumi, Albring, Jörn, Wu, Xiaodi, Tussiwand, Roxane, Wumesh, KC, Kretzer, Nicole M., Briseño, Carlos G., Durai, Vivek, Bagadia, Prachi, Haldar, Malay, Schönheit, Jörg, Rosenbauer, Frank, Murphy, Theresa L., Murphy, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507574/
https://ncbi.nlm.nih.gov/pubmed/26054719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3197
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