Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: Results from a pilot clinical study

Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop resistance to primary castrating therapy and secondary androgen deprivation therapies (ADTs). Resistance develops in par...

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Udgivet i:Sci Transl Med
Main Authors: Schweizer, Michael T., Antonarakis, Emmanuel S., Wang, Hao, Ajiboye, A. Seun, Spitz, Avery, Cao, Haiyi, Luo, Jun, Haffner, Michael C., Yegnasubramanian, Srinivasan, Carducci, Michael A., Eisenberger, Mario A., Isaacs, John T., Denmeade, Samuel R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507510/
https://ncbi.nlm.nih.gov/pubmed/25568070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010563
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