Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen

The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response wi...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Schneider, Zita, Jani, Péter Károly, Szikora, Bence, Végh, Attila, Kövesdi, Dorottya, Iliás, Attila, Cervenak, Judit, Balogh, Péter, Kurucz, István, Kacskovics, Imre
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507463/
https://ncbi.nlm.nih.gov/pubmed/26257730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00357
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