Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen

The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transport, and antigen presentation of IgG-opsonized antigens. Previously, we reported that transgenic (Tg) mice that overexpress the bovine FcRn (bFcRn) have augmented T-dependent humoral immune response wi...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Schneider, Zita, Jani, Péter Károly, Szikora, Bence, Végh, Attila, Kövesdi, Dorottya, Iliás, Attila, Cervenak, Judit, Balogh, Péter, Kurucz, István, Kacskovics, Imre
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507463/
https://ncbi.nlm.nih.gov/pubmed/26257730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00357
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