Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability

Spinal muscular atrophy (SMA) presents severe muscle weakness with limited motor neuron (MN) loss at an early stage, suggesting potential functional alterations in MNs that contribute to SMA symptom presentation. Using SMA induced pluripotent stem cells (iPSCs), we found that SMA MNs displayed hyper...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Liu, Huisheng, Lu, Jianfeng, Chen, Hong, Du, Zhongwei, Li, Xue-Jun, Zhang, Su-Chun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507262/
https://ncbi.nlm.nih.gov/pubmed/26190808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12189
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