Survival Motor Neuron Protein in Motor Neurons Determines Synaptic Integrity in Spinal Muscular Atrophy

The inherited motor neuron disease spinal muscular atrophy (SMA) is caused by deficient expression of survival motor neuron (SMN) protein and results in severe muscle weakness. In SMA mice, synaptic dysfunction of both neuromuscular junctions (NMJs) and central sensorimotor synapses precedes motor n...

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Main Authors: Martinez, Tara L., Kong, Lingling, Wang, Xueyong, Osborne, Melissa A., Crowder, Melissa E., Van Meerbeke, James P., Xu, Xixi, Davis, Crystal, Wooley, Joe, Goldhamer, David J., Lutz, Cathleen M., Rich, Mark M., Sumner, Charlotte J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462658/
https://ncbi.nlm.nih.gov/pubmed/22723710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0204-12.2012
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