O-glycans direct selectin ligands to lipid rafts on leukocytes

Palmitoylated cysteines typically target transmembrane proteins to domains enriched in cholesterol and sphingolipids (lipid rafts). P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD44 are O-glycosylated proteins on leukocytes that associate with lipid rafts. During inflammation, they transduce...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shao, Bojing, Yago, Tadayuki, Setiadi, Hendra, Wang, Ying, Mehta-D’souza, Padmaja, Fu, Jianxin, Crocker, Paul R., Rodgers, William, Xia, Lijun, McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507194/
https://ncbi.nlm.nih.gov/pubmed/26124096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507712112
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