Signal-dependent Slow Leukocyte Rolling Does Not Require Cytoskeletal Anchorage of P-selectin Glycoprotein Ligand-1 (PSGL-1) or Integrin α(L)β(2)

In inflamed venules, neutrophils roll on P- or E-selectin, engage P-selectin glycoprotein ligand-1 (PSGL-1), and signal extension of integrin α(L)β(2) in a low affinity state to slow rolling on intercellular adhesion molecule-1 (ICAM-1). Cytoskeleton-dependent receptor clustering often triggers sign...

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Detalhes bibliográficos
Main Authors: Shao, Bojing, Yago, Tadayuki, Coghill, Phillip A., Klopocki, Arkadiusz G., Mehta-D'souza, Padmaja, Schmidtke, David W., Rodgers, William, McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365994/
https://ncbi.nlm.nih.gov/pubmed/22511754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361519
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