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Catalytic Roles of βLys87 in Tryptophan Synthase: (15)N Solid State NMR Studies
The proposed mechanism for tryptophan synthase shows βLys87 playing multiple catalytic roles: it bonds to the PLP cofactor, activates C4′ for nucleophilic attack via a protonated Schiff base nitrogen, and abstracts and returns protons to PLP-bound substrates (i.e. acid-base catalysis). ε-(15)N-lysin...
Shranjeno v:
| izdano v: | Biochim Biophys Acta |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506891/ https://ncbi.nlm.nih.gov/pubmed/25688830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.02.003 |
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