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Directed Evolution of RebH for Site Selective Halogenation of Large, Biologically Active Molecules()

We recently characterized the substrate scope of wild-type RebH and evolved variants of this enzyme with improved stability for biocatalysis. The substrate scopes of both RebH and the stabilized variants, however, are limited primarily to compounds similar in size to tryptophan. We have now used a s...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Payne, James T., Poor, Catherine B., Lewis, Jared C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506780/
https://ncbi.nlm.nih.gov/pubmed/25678465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411901
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