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Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy
Chaperone-mediated autophagy (CMA), a selective form of degradation of cytosolic proteins in lysosomes, contributes to maintenance of proteostasis and to the cellular adaptation to stress. CMA substrates are delivered by a cytosolic chaperone to the lysosomal surface, where upon unfolding, are inter...
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| Publicado en: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506737/ https://ncbi.nlm.nih.gov/pubmed/26118642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.030 |
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