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Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
The proteasome is a highly regulated protease complex fundamental for cell homeostasis and controlled cell cycle progression. It functions by removing a wide range of specifically tagged proteins, including key cellular regulators. Here we present the structure of the human 20S proteasome core bound...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Pub. Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506541/ https://ncbi.nlm.nih.gov/pubmed/26133119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8573 |
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