Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation

Quinoline derivative SGI-1027 (N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-4-(quinolin-4-ylamino)benzamide) was first described in 2009 as a potent inhibitor of DNA methyltransferase (DNMT) 1, 3A and 3B. Based on molecular modeling studies, performed using the crystal structure of Haemophilus...

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Pubblicato in:ChemMedChem
Autori principali: Rilova, Elodie, Erdmann, Alexandre, Gros, Christina, Masson, Véronique, Aussagues, Yannick, Poughon-Cassabois, Valérie, Rajavelu, Arumugam, Jeltsch, Albert, Menon, Yoann, Novosad, Natacha, Gregoire, Jean-Marc, Vispé, Stéphane, Schambel, Philippe, Ausseil, Fréderic, Sautel, François, Arimondo, Paola B, Cantagrel, Frédéric
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY-VCH Verlag 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506529/
https://ncbi.nlm.nih.gov/pubmed/24678024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300420
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