Conversion of abiraterone to D4A drives antitumor activity in prostate cancer

Prostate cancer resistance to castration occurs because tumors acquire the metabolic capability of converting precursor steroids to 5α-dihydrotestosterone (DHT), promoting signaling by the androgen receptor (AR) and the development of castration-resistant prostate cancer (CRPC)(1–3). Essential for r...

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Bibliographic Details
Published in:Nature
Main Authors: Li, Zhenfei, Bishop, Andrew, Alyamani, Mohammad, Garcia, Jorge A., Dreicer, Robert, Bunch, Dustin, Liu, Jiayan, Upadhyay, Sunil K., Auchus, Richard J., Sharifi, Nima
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506215/
https://ncbi.nlm.nih.gov/pubmed/26030522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14406
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