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Conversion of abiraterone to D4A drives antitumor activity in prostate cancer
Prostate cancer resistance to castration occurs because tumors acquire the metabolic capability of converting precursor steroids to 5α-dihydrotestosterone (DHT), promoting signaling by the androgen receptor (AR) and the development of castration-resistant prostate cancer (CRPC)(1–3). Essential for r...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506215/ https://ncbi.nlm.nih.gov/pubmed/26030522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14406 |
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