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Function of the M1 π-helix in endplate receptor activation and desensitization
KEY POINTS: A conserved proline in M1 causes a kink between α and π helical segments. . The kink is under greater tension in the resting versus active conformation. . The kink and the agonist do not interact directly. . The π-helix separates the gating functions of the extracellular and transmembran...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506185/ https://ncbi.nlm.nih.gov/pubmed/25929452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270223 |
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