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Using Unnatural Amino Acid Mutagenesis to Probe the Regulation of PRMT1()

Protein arginine methyltransferase 1 (PRMT1)-dependent methylation contributes to the onset and progression of numerous diseases (e.g., cancer, heart disease, ALS), however, the regulatory mechanisms that control PRMT1 activity are relatively unexplored. We therefore set out to decipher how phosphor...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Rust, Heather L., Subramanian, Venkataraman, West, Graham M., Young, Douglas D., Schultz, Peter, G., Thompson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505744/
https://ncbi.nlm.nih.gov/pubmed/24358983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400859z
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