The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA, was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) and herpes simplex virus 1 (HSV-1) infection by inhibiting both viral-DNA replication and transcription. Through the u...

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Publicado en:J Virol
Autores principales: Lo Cigno, Irene, De Andrea, Marco, Borgogna, Cinzia, Albertini, Silvia, Landini, Manuela M., Peretti, Alberto, Johnson, Karen E., Chandran, Bala, Landolfo, Santo, Gariglio, Marisa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505635/
https://ncbi.nlm.nih.gov/pubmed/25972554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00013-15
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