Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics

G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the cell. However, the inside surface of the receptors that couple to G proteins has not yet been effectively modulated for activity or treatmen...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Zhang, Ping, Leger, Andrew J., Baleja, James D., Rana, Rajashree, Corlin, Tiffany, Nguyen, Nga, Koukos, Georgios, Bohm, Andrew, Covic, Lidija, Kuliopulos, Athan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505487/
https://ncbi.nlm.nih.gov/pubmed/25934391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636316
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