Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Cooper, Roland A., Conrad, Melissa D., Watson, Quentin D., Huezo, Stephanie J., Ninsiima, Harriet, Tumwebaze, Patrick, Nsobya, Samuel L., Rosenthal, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505276/
https://ncbi.nlm.nih.gov/pubmed/26033725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00921-15
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