Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all isolates were highly sensitive to dihydroartemisinin (DHA). By the ring-stage survival assay, after a 6-h DHA pulse, parasitemia was undetectable in 40 of 43 cultures...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Cooper, Roland A., Conrad, Melissa D., Watson, Quentin D., Huezo, Stephanie J., Ninsiima, Harriet, Tumwebaze, Patrick, Nsobya, Samuel L., Rosenthal, Philip J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505276/
https://ncbi.nlm.nih.gov/pubmed/26033725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00921-15
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