Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth the odds of symptomatic malaria compared to t...

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Udgivet i:Malar J
Main Authors: Tukwasibwe, Stephen, Tumwebaze, Patrick, Conrad, Melissa, Arinaitwe, Emmanuel, Kamya, Moses R., Dorsey, Grant, Nsobya, Samuel L., Greenhouse, Bryan, Rosenthal, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361791/
https://ncbi.nlm.nih.gov/pubmed/28327148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-017-1777-0
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