Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage

Incomplete APOBEC3G/F neutralization by a defective HIV-1Vif protein can promote genetic diversification by inducing G-to-A mutations in the HIV-1 genome. The HIV-1 Env V3 loop, critical for coreceptor usage, contains several putative APOBEC3G/F target sites. Here, we determined if APOBEC3G/F, in th...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Alteri, Claudia, Surdo, Matteo, Bellocchi, Maria Concetta, Saccomandi, Patrizia, Continenza, Fabio, Armenia, Daniele, Parrotta, Lucia, Carioti, Luca, Costa, Giosuè, Fourati, Slim, Di Santo, Fabiola, Scutari, Rossana, Barbaliscia, Silvia, Fedele, Valentina, Carta, Stefania, Balestra, Emanuela, Alcaro, Stefano, Marcelin, Anne Genevieve, Calvez, Vincent, Ceccherini-Silberstein, Francesca, Artese, Anna, Perno, Carlo Federico, Svicher, Valentina
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505216/
https://ncbi.nlm.nih.gov/pubmed/26055363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00137-15
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